Trypanosomes or platelet artefacts? A morphological dilemma!

Stormorken syndrome or York platelet syndrome: A clinician's dilemma

We read the paper recently published by Markello et al. in the latest issue [1]. Analysis of our observations [2] together with a review of other cases [3,4] suggests that patients with the c.910CNT mutation in STIM1 gene (p.R304W) have the same heterogeneous disease and that Stormorken syndrome (StS) and York platelet syndrome (YPS) are probably two different names for the same clinical condit...

Prophylactic platelet transfusion in dengue: A dilemma.

Glycosome biogenesis in trypanosomes and the de novo dilemma

Trypanosomatid parasites, including Trypanosoma and Leishmania, are the causative agents of lethal diseases threatening millions of people around the world. These organisms compartmentalize glycolysis in essential, specialized peroxisomes called glycosomes. Peroxisome proliferation can occur through growth and division of existing organelles and de novo biogenesis from the endoplasmic reticulum...

autoimmune hepatitis or wilson’s disease, a clinical dilemma

Species concepts for trypanosomes: from morphological to molecular definitions?

The way species and subspecies names are applied in African trypanosomes of subgenera Trypanozoon and Nannomonas is reviewed in the light of data from molecular taxonomy. In subgenus Trypanozoon the taxonomic importance of pathogenicity, host range and distribution appear to have been inflated relative to actual levels of genetic divergence. The opposite is true for subgenus Nannomonas, where c...